Posted by b2chica on August 2, 2012, at 12:24:19
In reply to Slow metabolizer / liver enzymes, posted by sheilac on July 25, 2012, at 13:27:52
i'm taking a pharmacology course right now and recently learned about this. completely agree with pdoc first of all.
BUT i have learned that (although genetic polymorphism studies is in its infancy) there is a Polymorphism in CYP(450)-an enzyme for metabolism- that responsible for major differences in drug metabolism. mainly on two enzymes: CYP2D6 and CYP2C19
many antidepressants, antipsychotics and other meds are dependant on CYP2D6
so if you have say no copies of the 2D6 gene your plasma concentration of the drug (amount of drug in your system)-lets say Nortriptyline- could be (say) 60% higher than for someone with 13 copies. or if a person took 10-hydroxynortriptyline (metabolite of Nort) that same person with 13 copies now can reach 200% concentration vs those with 0 copies.
i know its vary dependant on the person, the amount of genes and the drug vs metabolite.
but i was glad that i could totally appreciate your circumstances regarding medication. and wanted to CERTAINLY express to you that there is NOTHING wrong with you. it is amazing how complex yet homeostatic our bodies are.
ps. your ethnic background could play a role regarding the genetic component as there are markedly expressed frequencies of genetic polymorphisms.
"What is madness, but nobility of soul at odds with circumstance.
The day is on Fire, and i know the purity of pure despair."