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Re: Why does Nardil cause urinary retention? » gilmourr

Posted by Tomatheus on July 10, 2012, at 17:19:56

In reply to Re: Why does Nardil cause urinary retention?, posted by gilmourr on July 10, 2012, at 13:52:31

Gilmourr,

Thank you for your reply. When I was putting the contents of the Nardil tablets that I was taking into enteric capsules, I used a product called PlasminPlus for the capsules. I ordered my PlasminPlus from herbalremedies.com and then emptied out the capsules and put the (crushed up) contents of my Nardil tablets into them. It is my understanding, however, that the PlasminPlus product may no longer be on the market. The herbalremedies.com site that I used to use says that the product has been discontinued. Another site that I came across said that the product wasn't in stock.

I did some searching on the Web and found a site called alibaba.com that appears to list several suppliers that sell empty enteric capsules, but it appears that all of the suppliers of empty enteric capsules listed on alibaba.com are based in China. Maybe somebody else here will know if there are any suppliers based in the U.S. (or perhaps somewhere like Canada, Europe, or Australia) that sell enteric capsules online, but as far as I know, there aren't any U.S.-based companies that sell empty enteric capsules on the Internet or elsewhere.

One option you might want to consider if you want to try protecting your Nardil tablets with an enteric coating is going to a compounding pharmacy. An enteric coating should not only protect the contents of Nardil tablets (the phenelzine, to be specific) from undergoing chemical degradation in the stomach, but it should also protect the phenelzine (and any hydrazine that might be in the tablets) from moisture. I would, however, think that it would be important to make sure that you bring your Nardil tablets to be compounded as soon as you get them from your pharmacy to avoid exposing the tablets to too much moisture. I know that some Nardil users who've posted on another site had some success compounding their Nardil, although I'm not sure if compounding the Nardil stopped any urinary retention that the patients may have been experiencing (compounding the medication did reportedly boost its effectiveness). I'm also not sure if the patients in question had their Nardil compounded so it would have an enteric coating or if they just had it compounded so it wouldn't dissolve as quickly. So, bringing your Nardil to a compounding pharmacy would be an experimental effort, to say the least, but I think that it might be a viable option if you really want to try an enteric-coated version of Nardil.

Although I had some success putting the contents of my Nardil tablets into enteric capsules as far as both side effects and effectiveness were concerned, I think that I should point out that my prediction that protecting Nardil with an enteric coating might help make the medication more effective and more tolerable for others is basically based on my own experimentation with different forms of the medication and the fact that many who were taking Nardil when the formulation was changed in 2003 reported a loss of effectiveness and an increased incidence of side effects after switching from the enteric-coated "old" Nardil to the film-coated "new" Nardil. So, there aren't any studies that have been conducted that show enteric-coated phenelzine to be superior to film-coated phenelzine. All of the evidence that I have to offer, as far as the effectiveness and tolerability of the various forms of Nardil are concerned, is anecdotal. However, the fact does remain that the "old" Nardil, which many long-time users of the medication found to be superior to the current version, contained pharmaceutical glaze, which both protects tablets from moisture and is used as enteric-coating material. The Nardil that's currently supplied to pharmacies in the U.S. and elsewhere does not have a coating made up of pharmaceutical glaze, and that's one of the reasons why I think that the medication isn't as effective or as tolerable for many users as it used to be.

Tomatheus


Dx: schizoaffective disorder

Taking Abilify and 6 supplements

tomatheus.blogspot.com


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