Posted by psychobot5000 on June 28, 2012, at 13:09:49
In reply to Re: Memantine for Depression - How long to wait?, posted by sk85 on June 23, 2012, at 17:18:46
> > >And I really hate memantine's effect on dopamine D2 receptor.
> > >
> > What can you specifically attribute to its effect on the D2 receptor?
> Aggravation and triggering of movement disorders. Also, for some people like me D2 agonism seems to be prodepressant rather than antidepressant. But yes there are apparently others that find it antidepressant.
There's some research that shows that D2/D3 agonists (and it's probably D3 that's most important in mood) preferentially tend to occupy D3 presynaptic autoreceptors that reduce synaptic dopamine in the area, causing a perverse reduction in D3 signalling that causes a flattening of affect.
My experience with D2 and D3 agonists (i.e. ropinirole and pramipexole) has born this out, i.e. a single small dose produced marked reductions in affect until the drug was out of my system. I am unsure whether there might be a dosing regimen of agents with D3 (a 'D2-like' receptor) that might prevent or supercede this phenomenon, i.e. perhaps with higher doses.