Posted by SLS on June 8, 2012, at 13:07:08
Low-Dose Ketamine May Be Effective for Resistant Depression
June 7, 2012 (Phoenix, Arizona) The administration of 6 low-dose intravenous infusions of the fast-acting drug ketamine over 2 weeks shows efficacy in improving symptoms in patients with treatment-resistant depression, new research shows.
Ketamine may rapidly reverse prefrontal cortexbased deficits in depression at the neurocircuitry level, leading to an amelioration of clinical symptoms," said study investigator James W. Murrough, MD, a research fellow in Mount Sinai's Mood and Anxiety Disorders Program in New York City.
After undergoing a washout of antidepression medication, patients were treated with a series of 6 intravenous infusions of low-dose ketamine (.5 mg/kg, which is about one quarter of the 2 mg/kg typically used as an anesthetic), administered 3 times a week over the 2 weeks. The patients were then monitored for up to 3 months or until a relapse.
The results showed a significant decrease in depression during the 2-week treatment phase, with an overall improvement in Montgomery-Åsberg Depression Rating Scale (MADRS) score from baseline to postinfusion number 6 of 22.8 points (mean baseline MADRS score, 32.1 ± 6.0; endpoint MARDS score, 9.3 ± 11.3).
As many as 70.8% (17 of 24 participants) had a reduction of 50% or more in their MADRS score at the study's endpoint, compared with baseline. The remaining 29.2% (7 of 24) were considered nonresponders.
Some see things as they are and ask why.
I dream of things that never were and ask why not.
- George Bernard Shaw