Posted by sk85 on June 5, 2012, at 10:33:27
In reply to Lou's request-TD can be permanent » Christ_empowered, posted by Lou Pilder on June 2, 2012, at 4:34:54
I don't how to deliver this, so that no one takes it as a depressing news, because that is not my point. I have a tardive dystonia (so not quite dyskinesia, but they are related). From what I have learned and experienced myself is that at least tardive dystonia seems to be quite reluctant to go away with time. I have it already for 4 years with stable symptoms.
Some of these newer medication related movement disorders don't seem to have nothing to do with oxidative damage as some of the posters above have suggested, although, in some older generation neuroleptics this can be a significant contributor. Although one can never be too safe and taking antioxidants can't hurt much either. It's just that one shouldn't fool him/herself into thinking that they will absolutely protect from TD.
I tend to believe that with some newer neuroleptics the risk of TD is very low or absent altogether. For example I have taken Seroquel to actually help with dystonia. Although it wasn't a wonder drug either, it certainly didn't make it worse. What helps me most is clomipramine. Perhaps because dystonia (and OCD) has something to do with malfunctioning basal ganglia and clomipramine works a lot on that brain structure. So my point is that even though drug induced movement disorders can be persisting it appears there are many remedies that one can try out once it has appeared, search the Pubmed and you'll find a lot of case reports. The best strategy to avoid permanent/persisting TD is IMHO to recognise it at the most earliest stage and withdrwa from the offending medication.