Posted by psychobot5000 on June 2, 2012, at 0:02:17
In reply to Re: Remeron or Zoloft more powerful on Serotonin?, posted by mogger on May 30, 2012, at 18:11:34
> Thanks bleauberry. I don't know why on epocrates.com when I do drug interactions the addition of 5htp to remeron is a contraindication and when I put 5htp with zoloft there is only a moderate caution. Interesting that you say that it blocks some serotonin receptors I didn't know that. Thanks again.
Bleauberry is correct that zoloft is the only one of the two drugs that raises levels of serotonin. However, meta-analyses seem to show Remeron is a slightly more powerful medication.
I don't know that there's any reason to believe that remeron's powerful H1-blocking capability would be antidepressant (though it'll likely make you kind of sleepy...), but the direct action on serotonin receptors (which zoloft largely lacks) is certainly important in that regard.
For what it's worth, it's probably unlikely that 5-HTP supplementation with either of those two will much increase the risk of serotonin syndrome. From everything I've read, 5-HTP supplementation tends not to significantly increase serotonin levels in the CNS, unless it's prescribed with an enzyme inhibitor (as physicians do in the UK).