Posted by sk85 on May 20, 2012, at 15:29:48
I've tried a numerous drugs boosting noradrenaline and this is what I can summarize:
reboxetine (Edronax) - gloomy thoughts, depressive, dangerously increased heart rate
atomoxetine (Strattera) - c**ppy feeling, increased depression, heart rate up
bupropion (Wellbutrin SR) - emotionality, increased depression, suicidal
milnacipran (Savella) - dangerously increased heart rate
agomelatine (not really an NRI but increase NA tone) - depressive ruminations, increased pessimism
So the overall pattern seems to be pro-depressogenic effects and IMO cardiovascular sensitivity. What I don't get is that a lot of people find NRI-s very effective for depression without pumping their resting heart rate to 110 and feeling like a whale **** on the bottom of the ocean. Could this be some sort of a sensitivity? And would this suggest something about my underlying psychiatric condition (I still don't have a clear diagnosis after 7 years)?