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Unable to tolerate NRI-s - confused as to why

Posted by sk85 on May 20, 2012, at 15:29:48

I've tried a numerous drugs boosting noradrenaline and this is what I can summarize:

reboxetine (Edronax) - gloomy thoughts, depressive, dangerously increased heart rate
atomoxetine (Strattera) - c**ppy feeling, increased depression, heart rate up
bupropion (Wellbutrin SR) - emotionality, increased depression, suicidal
milnacipran (Savella) - dangerously increased heart rate
agomelatine (not really an NRI but increase NA tone) - depressive ruminations, increased pessimism

So the overall pattern seems to be pro-depressogenic effects and IMO cardiovascular sensitivity. What I don't get is that a lot of people find NRI-s very effective for depression without pumping their resting heart rate to 110 and feeling like a whale **** on the bottom of the ocean. Could this be some sort of a sensitivity? And would this suggest something about my underlying psychiatric condition (I still don't have a clear diagnosis after 7 years)?

-Ikaros


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poster:sk85 thread:1018303
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