Posted by SLS on May 16, 2012, at 6:16:44
In reply to Re: What will work for my panic disorder + MDD??, posted by bleauberry on May 16, 2012, at 5:09:57
> Savella. And if you combine it with the antidepressant you have found most agreeable thus far, then you'll have more control to customize the ratio of NE and 5ht.
> Cymbalta norepinephrine to serotonin ratio is 1:9.
> Effexor is 1:30.
> Savella is 3:2.
Haven't we already been through this? The occupancy ratio of Effexor for the SERT:NET at 300 mg is closer to 1:1. It has been measured as being 1.4:1. Again, binding affinity is not the only property to be considered when assessing its pharmacodynamics.
Our personal theories don't always match clinical observations.
I am not impressed with Savella as an antidepressant. I just don't see it working for people who try it. I'm sure some people respond to it, but I think Effexor has a better chance of working.
Some see things as they are and ask why.
I dream of things that never were and ask why not.
- George Bernard Shaw