Posted by bleauberry on May 16, 2012, at 5:09:57
In reply to What will work for my panic disorder + MDD??, posted by gilmourr on May 15, 2012, at 16:01:16
Savella. And if you combine it with the antidepressant you have found most agreeable thus far, then you'll have more control to customize the ratio of NE and 5ht.
Cymbalta norepinephrine to serotonin ratio is 1:9.
Effexor is 1:30.
Savella is 3:2.
I would be tempted to think along the same lines as you are, that NE is a player in this case. If that turns out to be true, then the above ratios would suggest why effexor didn't work, cymbalta did a little bit, and why savella might have some potential for you.
Another approach is to combine a TCA with SSRI.
During the first few days of savella sleep was horrible for me. But after that I had some really good sleep. And it was the only med that did anything for me after failing ECT.