Posted by bleauberry on May 1, 2012, at 7:20:03
In reply to different reactions to percocet, posted by alchemy on April 30, 2012, at 14:14:12
That's an interesting observation. I have noticed similar trends with vicodin, which is basically a close relative of percocet.
Vicodin is one of my "parachutes"....it doesn't work well for me if I take it all the time, but on those days when things are really really bad, it can rescue me from a deep fall. The weird thing is, the drug is in and out pretty quick. There shouldn't be hardly any left in the bloodstream by the next day. But, I get very significant benefits from it the day after. And similar to what you experienced, I feel a mix of calming and stimulation but each comes at a different time and they are not always predictable.
My best guess as to what is happening.....
There are things that have affinity for our opioid receptors, things that crowd out or compete with our own opioids. Whatever those things are, they squash out some of our opioids. But percocet or vicodin have a stronger affinity than the other things do, so they competitively displace whatever else is there. And 24 hours later the other stuff whatever it was has not yet had a chance to fully take over again. The things or other stuff I'm talking about are toxins....poop, pee, and defensive chemicals of infectious pathogens....maybe heavy metals too.