Posted by SLS on April 28, 2012, at 12:08:33
In reply to Re: i cant even smile. » bleauberry, posted by europerep on April 28, 2012, at 11:13:14
> > With any med however, the ratio is fixed.
>
> That's not true actually. At low doses, venlafaxine has less NE reuptake inhibition than fluoxetine, but venlafaxine becomes a SNRI at doses of 300mg and upwards.You are probably right. This must be what happens when one continues to raise the dosage beyond the point where the SERT binding sites have become saturated with the drug.
Who really knows all the ways in which venlafaxine differs from drugs like sertraline and nortriptyline. The bottom line is to observe what works in real life. Effexor works. My impression is that Savella is not as effective as Effexor in terms of the percentage of people achieving remission. To my knowledge, there is only one study comparing the efficacies of Effexor and Savella. The two drugs were reported to be equally effective at a dosage of 200 mg. Knowing the dosage is important because Effexor becomes fully effective at dosages of 300 mg and higher, while there is no evidence that milnacipran is any more effective at dosages above 200 mg. The manufacturer of Savella lists 200 mg as the maximum dosage while that of Effexor lists the maximum of this drug at 375 mg. It was never a fair fight. It can be inferred from this study that Effexor is more effective than Savella as the rate of response increases substantially when dosages of Effexor are brought up to 300 mg or more, but not when dosages of Savella are increased.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854083/
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1016383
URL: http://www.dr-bob.org/babble/20120425/msgs/1016616.html