Posted by tensor on April 24, 2012, at 23:43:40
In reply to Re: Abilify vs Seroquel, posted by Christ_empowered on April 24, 2012, at 17:13:53
> I respond well to Abilify (I currently take 30mgs/day for bipolar I, probably reducing slowly, hopefully soon). Seroquel made me angry.
Any problems with akathisia and nausea? I know those were issues for me, the nausea went away after a couple of weeks.
> Just based on the weight and metabolic issues and the intense sedation seroquel causes, I'd pick Abilify. When I needed a full dose antipsychotic AND some sedation, my doc gave me Abilify (20mgs)+Klonopin+PRN Ambien.
Yeah, Seroquel has the metabolic problems and Abilify seems to be more prone to cause akathisia and TD. Although very dose-dependent.
> That's just me. Abilify still caused considerable weight gain, and for me it seemed to be related to dose. Some weight gain at 15, more at 20, lots at 30. Probably still better than seroquel in that department, though, at least for most people.
> If you're going to low dose it, I'd take Abilify. Abilify does *something* at tiny doses. Tiny doses of Seroquel just act as a sedating antihistamine.
I'm taking Seroquel 200-300mg now with 50mg of Lamictal (going up to 100mg tomorrow) and 45mg of Remeron. The last week with Seroquel onboard I have problems with early awakenings and almost impossible to fall asleep again. I blame the NET effect from Seroquel for this.
I'm taking these meds for TRD MDD and I'm starting to feel something, not sure yet, but it feels positive. Anyway, I do not need the antimanic effect from the AAPs, so if I were to choose Abilify again I would probably take max 7.5mg/day.
The idea from the beginning was the Abilify-Lamictal combo, but I had to titrate up Lamictal before adding Abilify. I was also taking nortrip back then, but I got problems with anxiety so I replaced nortrip with Seroquel. And now I'm not sure if I should keep Seroquel while reaching target dose of Lamictal (100mg or 200mg?) or switch to Abilify now.
Primarily it's the efficacy of the med that counts. However, chances are that I will take either of these meds indefinitely so the long-term effects are also important. Perhaps in the lower dosing range it doesn't matter which one you choose.