Posted by SLS on April 21, 2012, at 12:37:08
In reply to Imipramine, Tryptophan, Sertraline combination., posted by Exisessentialist on April 20, 2012, at 21:00:15
> I tried to post this earlier but I think it may have been lost in the interwebs. I've been taking Sertraline 200 mg and Tryptophan 8 grams for approximately three weeks. My psychiatrist recently recommended that I add imipramine 25 mgs three times daily in an attempt to overcome my treatment-resistant depression. Has anyone tried the combination of these three before? I've recently been reading interesting things about combining TCAs and SSRIs on this and other sites. Would this combination be generally safe and advisable to take?
Perhaps you can talk with your doctor about the advantages and disadvantages of using nortriptyline in place of imipramine. Nortriptyline has more mild side effects and is not too heavy on serotonin. It is possible that he wants to use imipramine for its more potent serotonin reuptake inhibitor properties. Of course, you already get that with sertraline. One might consider that adding imipramine places too much of a serotonin load on the system. You would need to screen for serotoinin syndrome. Either way, I hope adding a TCA produces a favorable response for you.
Some see things as they are and ask why.
I dream of things that never were and ask why not.
- George Bernard Shaw