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Re: Has anyone tried prazosin? g_g_g_unit

Posted by SLS on March 28, 2012, at 6:41:34

In reply to Re: Has anyone tried prazosin?, posted by g_g_g_unit on March 28, 2012, at 4:31:20

> For the record, Prazosin is available to order online. I may do just that if my p-doc isn't willing to prescribe it.

I still have not "recommended" prazosin to anyone so much as document my experiences with it and disseminate some facts about this drug. Oh, yeah... and offer some silly theories regarding its observed efficacy in treating my depression successfully.

Prazosin (Minipress) is usually a benign drug. Side effects are few and tend to disappear quickly. The startup side effects include dizziness, fatigue, weakness, and sleepiness. I got past these things before two weeks had passed. Of course, as with any drug, any sign of hives or a rash should be reported to your doctor promptly.

The one side effect of prazosin that has persisted for me is a decrease in sex drive (libido).

My best guess as to the dosage range for treating depression is 3 - 9 mg/day. I am having great results at 6 mg for which I take 2 mg three times a day. Dosing three times a day is important because prazosin has a short half life: 2 - 3 hours. It is best to start at a low dosage. Maybe 1 mg at night. I believe 3 mg/day will work for some people, so it makes sense to stay there for a week or so before increasing the dosage again. I experienced an improvement at 3 mg/day that was uneven throughout the day. Out of a sense of urgency, I popped up to 6 mg/day, and here I am.

All I can say is that when I added prazosin to my other medication it felt like a powerful and clean antidepressant. Since anxiety hasn't been so much of a problem in recent years, I can't comment on its anxiolytic properties. However, in studies of PTSD, prazosin has produced improvements in daytime anxiety and depression. This is in addition to its ability to reduce nightmares and improve sleep.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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