Posted by ed_uk2010 on February 27, 2012, at 1:25:15
In reply to Re: Ed_uk2010 - are you there? » ed_uk2010, posted by Maisey on February 26, 2012, at 11:37:31
>I also read that in generics in the U.S., the generic formulation can have up to 20% variance to the original's formulation. And, in tests of some drugs, 30% variance was found! So, that worries me a little bit - not knowing India's standards.
India has a substantial pharmaceutical industry. A lot of generics and branded medicines are made (for the rest of the world) in India. The problem isn't where your medication was made, it's the issue of whether it's actually a genuine product. Some medicines sold over the internet are fakes.
Assuming your medicine is genuine, Cipralex is not a generic. Cipralex is the brand name used by the manufacturer, Lundbeck, in many countries, including the UK.
US generics do not differ from the brand by 20% in terms of formulation. The quantity of drug contained in the tablets is exactly the same as the brand. The 20% figure is part of a statistical bio-availability calculation, and is often misquoted.
>I think I'll be OK going off this cold turkey since it's only a 5mg dose.
I think you'll be OK to just stop. To be honest, I think you would feel much safer taking something from your doctor. You could try generic sertraline (Zoloft), starting at a low dose initially. Sometimes people get worse before they get better, but it's generally a useful medicine. Alternatively, you could ask your doctor about taking a higher dose of amitriptyline, since you are already used to this medication.