Posted by ed_uk2010 on February 17, 2012, at 14:32:37
In reply to Depakote questions, posted by g_g_g_unit on February 16, 2012, at 21:40:17
>I went from feeling bleary-eyed and exhausted to being unable to fall asleep until 3am.
> Is this a weird reaction?
Not that weird. Insomnia has been reported in clinical trials of valproate. I've heard that it occurs most often in children, but also in adults in some cases, especially at high doses.
>Also, if I'm only taking the IR (no ER in Australia), would there likely be withdrawal during the day?
Most valproate tablets are enteric-coated (gastro-resistant). This does delay the release of valproate to some extent. There are also some sustained-release formulations eg. Epilim Chrono in the UK.