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Re: q's for those who are, or have been, on Parnate » SLS

Posted by g_g_g_unit on January 31, 2012, at 5:19:23

In reply to Re: q's for those who are, or have been, on Parnate » g_g_g_unit, posted by SLS on January 31, 2012, at 4:59:55

> > 1. Did you notice any significant difference in effect once you passed a certain threshold, i.e. 60mg? Last time I was prescribed the drug, my psychiatrist wouldn't raise the dose above 40mg, though I've read of several people who found a significant improvement in anxiety etc. only once they reached 60mg.
>
> Having had much experience with Parnate and working with several doctors, I can say with confidence that true therapeutic dosage range for Parnate is 40-80 mg/day.

Did you ever experience an initial exacerbation of depression, especially on lower doses?

If there wasn't any improvement gleaned at 40mg (though I only stayed on the dose for 2 weeks, before discontinuing), do you see any logic in returning to Parnate at 60mg? The reason I ask is because my living situation is becoming so dire that I'm not sure I can afford to waste any more time on pointless drug trials. Right now, the only thing I can think about is dying. I mention that only to give a general idea of my mindset and how bad things are for me - I know it's the depression at work, but I feel like I need some kind of miracle.


>
> > 2. Does the drug have any positive/neutral effects on cognition?
>
> I find that it is neutral. However, cognition will improve as depression improves. If you do experience "brain-fog" or "spaciness" in the beginning, these things should pass.

Yes, spaciness was definitely an issue last time, though I experience so much brain-fog and spaciness in my current depressed state that I was hoping Parnate might improve those things.
>
> > Does the initial stimulant effect fade,
>
> I'm not sure what you mean by "stimulant effect". How would you describe it?

Hmm. Well, I recall lower doses feeling very much akin to Dexedrine - i.e. mild euphoria, improved concentration, energy, motivation etc. At higher doses, i.e. 30mg, the effect turned nastier and increased anxiety and irritability. Dr Gillman informed me that Parnate doesn't metabolize to amphetamine (though there does seem to be a circulating myth along those lines). But regardless, I often read about people reporting an initial stimulant-like effect, which fades with time. I was wondering if likewise any improvements in attention, motivation and anhedonia might fade too.

>
> > 3. Did sleep improve at higher doses, i.e. 50-60mg?
>
> That has not been my experience with Parnate. Where did you get this idea from?
>

Again, I believe I've read accounts from e.g. bulldog2, maybe JadeKelly, who mentioned that the insomnia eased up a bit at higher doses. Here's a quote from bulldog2:

"I finally reached 60 mg and stayed there 2 weeks ...The insomnia went away and I slept okay."

 

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