Posted by DavidR11 on December 20, 2011, at 0:37:25
In reply to Re: Has anyone tried Deplin, posted by poser938 on December 19, 2011, at 15:31:14
Poser938-
Im familiar with Deplin and will attempt to answer how Deplin, which is a high dose of L-methylfolate, may work. Anything over 1mg of L-methylfolate has to be in a prescription form which may clarify why it is hard to find. Deplin actually has emperical studies that demonstrate efficacy over placebo. Folic acid does not cross the blood brain barrier, only the converted form L-methylfolate. L-methylfolate is required for BH4, BH4 is required for Tryptophan and Tyrosine. More Tryptophan and Tyrosine are needed for the three neurotransmitters. More neurotransmitters may mean addressing depression, hence the SNRIs and SSRIs with "re-uptake". As much as 70% of depressed patients may be folate deficient, requiring adequate folate. Hope this helps!
poster:DavidR11
thread:1005205
URL: http://www.dr-bob.org/babble/20111208/msgs/1005275.html