Posted by Phidippus on November 23, 2011, at 18:22:36
In reply to Namenda Augmentation, posted by TxMex on November 23, 2011, at 1:53:05
I have used Namenda in the past to augment treatment for OCD. I can say overall it was very helpful and provided benefits to my mood as well. I remember having some OCD free days while on Namenda and at the same time feeling very up.
NMDA antagonists are well studied now for their positive affect on depression, in particular Ketamine, which seems to have very robust effects on depression, sometimes resolving it in a day. Namenda is not nearly as strong an NMDA antagonist as Ketamine, but its cumulative effects should be worth a trial.
You should also know that Namenda has a pretty complex method of action. Besides NMDA antagonism, Namenda acts as a non-competitive antagonist at the 5-HT3 receptor, with a potency similar to that for the NMDA receptor. The 5-HT3 receptor is implicated in anxiety.
Namenda acts as a non-competitive antagonist at different neuronal nicotinic acetylcholine receptors (nAChRs) at potencies possibly similar to the NMDA and 5-HT3 receptors. What effect this will have on depression remains to be seen.
Also, NAmenda acts as an agonist at the dopamine D2 receptor. This should provide some help with the anhedonia you are experiencing.
All in all, I think Namenda is a great drug with a low side effect profile. It may just help with some of the issues you are experiencing.
Eric
DX: ADHD/BP NOS/OCD
RX: Lithium 1200 mg, Latuda 40 mg, Vyvanse 60 mg, Lyrica 600 mg, Viibryd 40 mg., Namenda 40 mg.
poster:Phidippus
thread:1003412
URL: http://www.dr-bob.org/babble/20111120/msgs/1003483.html