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Re: Amitriptylin vs. Doxepin and weight

Posted by linkadge on September 28, 2011, at 20:16:57

In reply to Re: Amitriptylin vs. Doxepin and weight, posted by jono_in_adelaide on September 28, 2011, at 19:14:04

I would (personally) think that doxapin might cause less weight gain for the following reason:

The weight gain is linked to both the h1 antagonism and the 5-ht2c antagonism, however, I believe more so due to the latter effect.

Doxapin is a more potent antihistamine than amitriptyline. It has a higher ration of h1 antagonism to 5-ht2c antagonism. The sleep inducing effect is probably more related to the h1 antagonism. So, with doxapin, you probably get more sedation at lower doses, meaning less potent 5-ht2c angtaonism therfore less weight gain?

Who knows though, but I personally think that doxapin was a more effective drug than amitriptyline.





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