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Re: Wellbutrin works, but while withdrawing? » desolationrower

Posted by SLS on June 18, 2011, at 4:36:10

In reply to Re: Wellbutrin works, but while withdrawing?, posted by desolationrower on June 14, 2011, at 20:01:22

Hi again.

> I have come across a few things on norepinephrine reuptake generally,

You might be right. I have never experienced a withdrawal rebound improvement with a SSRI or SNRI.

> but i can't remember it the way i can remember the 5ht story of "reuptake overloads presynaptic autoreceptors within hours,

Yup!

:-)

> causing lowered 5ht release and firing rates until the autoreceptors desensitize and recede over the course of 1-3 weeks".

Yup!

This is why pindolol, a 5-HT1a somatodendritic autoreceptor antagonist, has been observed to "hasten" or accelerate an antidepressant response to SRIs. It buffers the effects of reuptake inhibition while receptors are reregulating themselves.

Thanks for posting this.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

 

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