Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

... And all things Nardil ... Re: Morning dread... » zonked

Posted by Questionmark on June 16, 2011, at 18:46:25

In reply to Morning dread..., posted by zonked on June 11, 2011, at 10:58:13

I have also been experiencing this. Every morning i wake with terrifying, excruciating depression and feelings of dread and anxiety-- and overwhelming sleepiness.

I have almost always taken Nardil 3x/day.
The past several years i have varied my dose a lot (i know, it sounds foolish, but i have my reasons), 45mg being the max and often trying my damnedest to maintain on less. Currently i am only taking 30mg and have recently begun taking it 4x a day, as an experiment.

I've been noticing that recently these morning issues seem to be worse than before (though mg per mg it's hard to tell), and i have recently started taking the new generic (Gavis) phenelzine. So i'm not sure as it could be due to other factors, but I've been wondering if the generic is metabolized somewhat faster or something. I hope not.
Others' thoughts on this would be appreciated.

But i have to disagree with a number of the other posters in saying that Nardil is probably not a factor in this morning phenomenon. I feel pretty strongly that the nature of Nardil is largely involved in this.
Despite the half-life supposedly being 11 hours, and despite MAO enzymes supposedly taking several days for the body to manufacture again, for whatever reason, experientially, Nardil has very temporally limited effects. After about 6 or so hours from my last dose, I start to notice a difference in how i feel-- worse mood, more drowsy, more susceptible to anxiety. I also notice that if i only get 4 or 5 hours of sleep, I do not wake with those same feelings of dread, etc as I normally do. Presumably because it has been less time since my last dose of Nardil.
Nardil is just so damn unpredictable. SSRIs seem to give the same effects from one hour or day to the next. On Nardil it seems as if random periods of low mood, and drowsiness in particular, are unavoidable. The problem is, part of what makes it so good is also what makes it so hard to figure out and define -- it's such a complicated drug. It affects so many different neurotransmitter systems as well as a few trace amines. Trying to make sense of it all is not easy.

I've spent so much time thinking about how best to use Nardil: what dose; what frequency of dosing; how do i eliminate the horrendous difficulty in waking, and the morning depression and fatigue; how do I make it have more smooth effects; and on and on. And now the side effects, which were tolerable before, are really starting to become a problem for me. .... I'm so tired of this whole merry-go-round.

You are right... if only there could be an extended release Nardil.


A few points though from my experience:

1) Splitting the doses definitely seems preferable (at least 3x/day).

2) The higher the dose -- or at least the higher the nighttime dose -- the less severe the negative morning effects.

3) The more evenly you can divide your doses, the better.


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Questionmark thread:987723
URL: http://www.dr-bob.org/babble/20110610/msgs/988380.html