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Re: ::Pls help:: chasing Wellbrutrin / topamax effects

Posted by mtdewcmu on May 10, 2011, at 21:22:15

In reply to Re: ::Pls help:: chasing Wellbrutrin / topamax effects, posted by desolationrower on May 3, 2011, at 21:24:54

> hm, i wonder if this might be related to bupropion vs its metabolites, which do more re norepinephrine and less dopamine.

I have stopped and restarted Wellbutrin several times lately, and it's always best at the beginning. I think the parent drug is pretty good, but after a few days the active metabolite accumulates and starts to overtake it in terms of effects. I had a pdoc tell me that the metabolite, hydroxybupropion, was the active part, and bupropion itself was essentially just a source of side effects. But I believe there was an attempt to turn the metabolite into an AD, and I think it's telling that it appears to have gone nowhere.

Not a doctor. Contact a doctor for medical advice.
20mg citalopram, 40mg d-amphetamine, 15mg mirtazapine, 300mg bupropion
dx: chronic MDD, probable ADHD (inattentive)




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