Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Any ACTUAL Experience w/Neuroreplete?

Posted by linkadge on March 6, 2011, at 14:55:13

In reply to Re: Any ACTUAL Experience w/Neuroreplete?, posted by MissThang on March 6, 2011, at 7:40:22

Thanks for the information.

No, I would never say that something won't work, cause I don't know.

But, yes I don't think there is a whole lot of evidence proving that iscolated amino acids are particularly effective for the treatment of depression.

Take dopa, for isntance. I does have proven utility for parkinsons, but dosage escalation is oftentimes necessary, it can cause side effects like mood swings and hallucinations. Also there is preliminary evidence that it can further destroy dopaminergic neurons.

Contrary to initial evidence, many antidepressants don't really increase monoamine levels. Take amitriptyline for instance (often used as a reference antidepressant). Many sources claim this drug works by increasing serotonin/norepinephrine levels. However, recent in vivo evidence suggests that the drug acts more potently as a serotonin antagonist (like mianserin) than an agonist. Also, the drug counteracts the ability of chronic stress to increase serotonin transmission in the dorsal raphai and frontal cortex.

I guess what I am saying is that the idea that depression is due to low serotonin / norepinephrine is so incredably simplistic, and theres not a lot of evidence showing that:

a) long term high dose amino acid therapy works for depression

b) high dose amino acids are safe (and not increasing oxidative amine metabolism) or causing further imbalances (or causing cardiac valve proliferation due to high peripherial serotonin)

c) urine tests for amino acids acurately reflect brain absorbtion / utilization of the neurotransmitter

amino acids may be out of ballance in depression, but how do you know its not low GABA vs low serotonin? Some depression is due to low gaba. Or low gylcine, or low taurine, or low PEA, or high histamine, or elevated glutamate, or imbalances in one of the many enzymes that synthesize the amino acid.

Linkadge



Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


[980175]

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:linkadge thread:980132
URL: http://www.dr-bob.org/babble/20110220/msgs/980175.html