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Re: Tramadol for TRD

Posted by sukarno on January 16, 2011, at 4:47:14

In reply to Re: Tramadol for TRD » roscopeeco, posted by emmanuel98 on January 10, 2011, at 21:08:26

How about dronabinol (Marinol) prescribed off-label for TRD without psychotic features? It is C-III, but in reality very few people abuse it and from what I can tell the side effects are not very pleasant. That said, there are anecdotes about it helping TRD. Perhaps nabilone or Sativex (available in Canada) would help too?

I wouldn't recommend it for anyone with anxiety or psychosis. For unipolar depression resistant to SSRIs, TCAs, MAOIs, ECT, etc, it might be worth a try.

I'm not sure if doctors prescribe it off label, even if you were inpatient and closely monitored.

At least there are no severe withdrawal symptoms. Any withdrawal from cannabinoids is mild due to the long half-life and it can be tapered off gradually. Opioids can be tapered too, but they are more problematic IMHO.


Rx: alprazolam 1mg QID, famotidine 20mg BID, cetirizine 10mg BID, GNC Ultra Mega Gold vitamin supplement BID

Dx: panic disorder with agoraphobia, chronic depression, probable PTSD


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