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Re: Agomelatine (Valdoxan) and Body Pains? » Bob

Posted by SLS on January 14, 2011, at 18:02:45

In reply to Re: Agomelatine (Valdoxan) and Body Pains?, posted by Bob on January 14, 2011, at 16:02:07

Hi Bob.

> Then there was my response to atypical antipsychotics. I learned over time that although there was an initial benefit with elevated mood and energy, the response would devolve into irritability and joint pain. The pain appeared in my knees, hands and arms. The higher the dose the worse the pain became.

Exactamundo! I have also been irritable over the last week.

> There is a truly mysterious link between this pain syndrome I have and my depression that is not understood by me, and neither has it been understood by any of my doctors.

Any PTSD history?

> It is truly confounding and scary. So having said that, I would not be surprised in the least if agomelatine was producing the pain you describe.

I skipped my nightly dose of agomelatine yesterday. The pain has subsided a great deal today, and my mood has improved. It appears that, for me, agomelatine is mildly depressive. This has been my second trial of agomelatine. Just like with the first one, the appearance of depressive side effects compelled me to abort the trial. My mother swears that I had complained of pain during my first trial. I really don't remember.

> I wish I knew what to say about continuing treat. Unfortunately as much as I hate to admit it, I do not recall an effective treatment where pain was present initially and then subsided.

That is the sort of information I was looking for.

Thanks much.

I really hope that you find an effective treatment soon.

I think we both know that finding a treatment regime that hits the target such as to produce a full remission could involve a lengthy series of clinical experiments. I am working toward finding a middle ground where I am improved enough to return to work while remaining motivated enough to continue searching for better treatments. The trick here is not to break what you have already fixed for the sake of putting more pieces together. I have settled on taking four different drugs consistently as a treatment regime in order to function well enough to get a job. I am tentatively looking at late spring or summer to begin applying for jobs. Between now and then, I may want to undergo a series of rTMS treatments while remaining on medication. The process would take at least four weeks, five days a week.

rTMS

$400 per treatment
1 treatment per day
5 days per week
4 week protocol

$8000 for the initial series of 20 treatments

$400 x ? maintenance treatments per year

If Medicare were to approve rTMS tomorrow, I would be in the treatment chair later that day.

I probably will not consider trying vilazodone when it first becomes available. For me to try vilazodone would require that I discontinue Nardil. After the drug has been out for awhile, we ought to get a better idea as to how effective it is and what subtypes of MDD and BD it is best suited for. The evidence would have to be very compelling before I risk employment to try it.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

 

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