Posted by Conundrum on December 30, 2010, at 10:31:37
In reply to Re: Anhedonia is wearing me down., posted by linkadge on December 30, 2010, at 8:27:58
> Is conundrum bipolar? Why/is he taking trileptal (?)
>
> LinkadgeMy pdoc thinks so. I actually talk about it in my reply to SLS. I had tried lamictal with no success. I'm hoping if low dose prozac increases my motivation for awhile I can say to her "Look it is holding my mood, now don't be scared and add on a TCA!"
I do not know if serotonergic meds are bad in this kind of environment, I can't speak for everyone, but I also do not respond to psychostimulants, with the exception of 2 bags of caffinated tea steeped in one mug, then followed by another mug of the same. Totally disgusting. I've tried budeprion SR, methylphenidate IR, mixed amphetamine IR, coffee, caffeine pills, and adrafinil. The only DA pharmaceutical to have any kind of response was abilify, which stopped after 2 days of making me do things with no pleasure. This tells me that 1) I am treatment resistant, 2) newer drugs that hit less targets, like abilify which only increases DA in one brain region are too "clean" for me and 3) I might be so depleted of catecholamines that short acting stimulants have no effect noticable effect. You can't get blood from a stone as they say.
I actually think the reason I do well on such a low dose of prozac is because it increase norepinephrine in the PFC via 5 HT2C antagonism and some 5 HT1A agonism. Higher doses just make me feel flat again. The feeling I get from low dose prozac is similar to the feeling I had for the few days remeron was working.
I wonder if the fact that prozac can decrease dopamine in the nucleus accumbens and that I felt so good on it as a teen, indicate that increasing dopamine is not necessary? Who knows. I'd really like to try a TCA, but I'd have to lose the mood instability dx to try that.
Complaints: post-SSRI problems: anhedonia, memory and concentration problems, sexual anhedonia. )
Country:USA
Currently taking 2.5 mg prozac, Multi B vitamin
poster:Conundrum
thread:975164
URL: http://www.dr-bob.org/babble/20101218/msgs/975241.html