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Re: Seroquel for unipolar depression » ace

Posted by sk85 on December 6, 2010, at 5:26:22

In reply to Re: Seroquel for unipolar depression » sk85, posted by ace on December 5, 2010, at 23:59:24

> On the whole, and after a great deal of research and observation and experience, i have not really seen the SSRI's to be off great value in the treatment of any psychopathology. They can have horrid withdrawal syndromes, a myriad of s/effects (sometimes totally unexpected ones).

I concur, SSRIs can be pretty messy drugs and their long-term effectiveness is very dubious. Thanks to Prozac I ended up with permanent dystonia and despite it's somewhat initial positive effects, it lost most of its effectiveness by the end of the 4 month. Absolutely pointless drug in my opinion.

> some pills have made me really depressed initially before giving an antidepressant effect.
>
> This, a lot of the time CAN, predict a very good therapeutic response. But even this phenomenon- the initial worsening of symptoms leading to a greater antidepressant effect-

Yes, I've experienced that aswell. For example Effexor made me feel really terrible for the first week, after that came enormous relief to most of my symptoms. But because Prozac made so much damage before it, I started getting worsening dystonia also on Effexor, so I had to discontinue it.

I don't think I can take anything that hits serotonin hard, because all of these attempts have ended up in terrible EPS. So TCA-s and MAOI-s are out for me. So far Seroquel has not made my condition worse (if not improved it significantly). Although my mood keeps dipping for no apparent reason, so I'm desperately searching for something to help. Mirtazapine is also one possible candidate.


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