Posted by ed_uk2010 on December 3, 2010, at 17:30:17
In reply to Re: TCA's Linked To Cardiovascular risk » ed_uk2010, posted by Conundrum on December 3, 2010, at 11:48:53
>Its nice to say the patient would have developed the disorder on their own...
TCAs can certainly induce arrhythmias. They alter cardiac conduction. TCA-induced arrthymias are especially likely at high doses, in overdose, and probably at normal doses in poor metabolisers. There is also a particular risk in those with underlying structural heart disease. As far as I am aware, the risk of arrhythmias goes away after the drugs have been stopped, and cardiac conduction returns to normal.