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Re: New drug for depression - Long wait until approval

Posted by SLS on November 22, 2010, at 7:13:17

In reply to Re: New drug for depression - Long wait until approval, posted by linkadge on November 22, 2010, at 6:53:21

> I remember when they were saying that the cortisol modulating drug RU-486 was being 'fast tracked' for psychotic depression. This was about 12 years ago.

Been there, done that. RU-486 (mifepristone) did not affect me any therapeutic way. However, after the full 8 days of treatment as recommended in the treatment protocol, I felt "washed-out". The adrenals were probably exhausted.

Alan Shatzberg was the leading investigator proposing mifeptistone as a treatment for psychotic depression. I corresponded with him as well as a European investigator whose name I don't remember off hand. After all was said and done, it seems that mifepristone can reduce the psychotic symptoms of psychotic depression without resolving the depression itself.

I guess the drug was fast-tracked, but ultimately failed to demonstrate efficacy in the accelerated schedule of studies.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.




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