Psycho-Babble Medication | about biological treatments | Framed
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Re: New drug for depression - Long wait until approval

Posted by linkadge on November 21, 2010, at 11:32:35

In reply to New drug for depression - Long wait until approval, posted by SLS on November 21, 2010, at 6:44:48

My personal thoughts are that purely neurotrophic agents are not going to routinely display antidepressant effects.

In the Flinders sensitive line (a breed of depressive rats) there is evidence of excessive hippocampal neurogenesis. Nortriptyline administration improves the behavioral deficits while *lowering* hippocampal neurogenesis.

Also, hippocampal volume loss is not present in all studies of depressed patients.

My thoughts are that this agent may be beneficial for a certain subgroup of depressed patients, or certain symptoms of depression, but not all.




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