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Re: Why does Nardil cause sexual side effects?

Posted by jms600 on November 11, 2010, at 15:19:51

In reply to Why does Nardil cause sexual side effects?, posted by Joe Schmoe on November 11, 2010, at 14:19:38

> Since I suffer from social anxiety I have always had an interest in Nardil, supposedly the "gold standard" for SA. It sounds like it has severe weight gain and sexual side effects for many people though.
>
> I was reading about it and apparently it raises the levels of dopamine as well as serotonin. This confused me, since I was also just reading about Vilazodone (with great hope) and it is supposed to not have sexual side effects, because its effect on the 5-HT1a autoreceptor somehow causes dopamine release. Similarly, Wellbutrin is often used to help with ssri sexual side effects because of its dopamine raising effect. I have often read that sexual disfunction caused by ssri's is due to their tendancy to suppress dopamine.
>
> If Nardil raises dopamine levels and not just serotonin, why does it still have sexual side effects?


I would guess it has something to do with one of the types of serotonin receptors it has an effect on. It's not a particularly selective drug unfortunately.


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