Posted by bleauberry on October 25, 2010, at 17:13:47
In reply to Alternate dosing question help, posted by rculater on October 25, 2010, at 11:26:29
I used to experience this same phenomenon, and others here have too. No one knows, but my best guess it is a dopamine/norepinephrine rebound. It only lasts a short time because that happens to be about the time it takes the feedback loops to figure out what is going on and then adjust to their genetic commands.
What this points to is the need for a catecholamine agent in conjunction with your ssri. Nortriptyline, Desipramine, Milnacipran, or Ritalin are good candidates.
Bottom line, the ssri is only hitting part of the problem. You are worried about ssri apathy, and for good reason. You just need to treat dopamine and norepinephrine with the same attention you are giving serotonin.
> Sorry a bit long winded - I suffer from dysthemia.atypical depression
>
> I always struggle on SSRis at about the month mark and panic that im going to gain weight, or get paranoid that im turning into a unmotivated apathetic procrastinating lazy being - this usually leads to an abrupt discontinuation.
>
> I've discovered that after a day or 2 after discontinuation, I feel great. This as happened on long term and short term failed treatments.
>
> The good mood obviously doesn't last long, a few days maybe then im back to stage 1.
>
> I was wondering if alternate dosing would be an answer. Currently been on 10mg lexapro for a month and im at the stage where im wondering if its worth it - I was thinking about taking one every other day ? Is that feasible ?
>
poster:bleauberry
thread:966924
URL: http://www.dr-bob.org/babble/20101020/msgs/966952.html