Posted by Nikos on October 21, 2010, at 2:41:00
In reply to Re: Take the NE edge off Bupropion XR » sregan, posted by linkadge on October 20, 2010, at 20:17:36
> Yes, omega-3 has been shown to lower norepinephrine and boost dopamine levels. Great for the heart, great for the brain.
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> LinkadgeI recommend an alpha2 agonist like clonidine or guanfacine, the latter causing more fatigue.You do not want to block the a2 receptors as this will increase norepinephrine and blood pressure as observed in medications like yohimbine.
Alpha1 blockade is alright and contributes to a small degree to the heart rate and bp lowering of beta blockers. I myself would not recommend beta blockers unless you have a background of tachycardia as they tend to lower heart rate too much.
Also beta blockers decrease nocturnal melatonin release, perhaps partly accounting for sleep disturbance caused by some agents.They also can impair the relaxation of bronchial muscle (mediated by beta-2) and so should be avoided by asthmatics or people which may have bronchitis.They are however very affective for social anxiety as seen in use/abuse in people doing public presentations or playing musical instruments in symphonies.
A2 agonists are used routinely in ADD or ADHD to remove the norepinephrine component with meds like methylphenidate or Stims yet leaving the dopamine synthesizing or re-uptake properties intact.I believe in theory that they may remove excessive norepinephrine activity in the Striatum and in this manner are effective for conditions like ADD, tourettes, OCD and stuttering which are mediated mostly in the head of the caudate nucleus.Best of luck.
poster:Nikos
thread:966347
URL: http://www.dr-bob.org/babble/20101020/msgs/966453.html