Posted by EmsamNewUser on July 24, 2010, at 23:49:15
It my research it seems clear that the initial 6mg dose is not typically sufficient to produce the antidepresant response (At lower doses, it inhibits only MAO-B, and only at higher doses does it lose its selectivity and thus also inhibits MAO-A, producing the antidepressant effect).
I need explicit documentation to spell this out for my doctor, yet the journal articles I read seem to discuss the mechanism of action in terms of "low dose" and "high dose" and then only toward the end refer in passing to ENSAM's 3 strength.
Is there any citation that explicitly links the dots to say something like the 6mg is typically sufficient for Parkinsonian, but not antidepressant uses and that at 6mg inhibits only MAO-B, and typically only at 9mg or 12mg doses does it lose its selectivity and thus also inhibits MAO-A, producing the antidepressant effect.
I have been on it for 2 weeks, with no antidepressant effect (some positive and negative side effects: great for weight loss, lowers blood pressure, but some insomia at night and lethargy in day). I want to head up to 9 but doctor wants to stay at 6 for at least a month, which seems pointless.
Also, is there any documentation (from doctors, not anecdotally) that modafinil is suitable in combination and also that it is ok to cut the patch. Thanks!