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Re: ...Or does it?

Posted by Brainbeard on June 29, 2010, at 17:50:16

In reply to Re: ...Or does it?, posted by linkadge on June 29, 2010, at 15:49:57

> Do you have any literature that buspar is a dopamine agonist??
>
> Also to corroberate what you say, 5-ht1a agonists are highly neuroprotective (at least to hippocampal neurons).
>
> Linkadge

Ha, this is a nice one: 'Buspirone in the treatment of tardive dyskinesia': http://www.ncbi.nlm.nih.gov/pubmed/8102622. ;)

From the great Medscape article on buspirone (http://www.medscape.com/druginfo/monograph?cid=med&drugid=74939&drugname=Buspirone+(Bulk)+Misc&monotype=monograph&secid=8):

'Buspirone appears to possess some dopamine agonist activity. Like apomorphine, buspirone produces weak turning behavior in lesioned animals and, like amantadine, potently reverses catalepsy induced by antipsychotic agents, suggesting that the drug has some dopamine agonist activity. Buspirone reportedly elevates plasma somatotropin (growth hormone) concentrations (see Neuroendocrine Effects), an effect possibly mediated by postsynaptic dopamine agonist activity in the hypothalamus.'


Current meds: sertraline 200mg; amitriptyline 50mg; melatonin 0.3mg. PRN: diazepam (Valium) 2.5-10mg.


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URL: http://www.dr-bob.org/babble/20100628/msgs/952644.html