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Re: Imipramine really that good? » med-amorphosis

Posted by SLS on May 17, 2010, at 14:57:24

In reply to Imipramine really that good?, posted by med-amorphosis on May 17, 2010, at 14:11:37

> Some sources say that imipramine is 'gold standard' for TRD and is unsurpassed when tested against newer antidepressants. Please share any experiences with it. Especially if uv used it with an MAOI. All comments wellcome. Thanks.
>
> My current regime is:
> 90mg isocarboxazid (Marplan).
> 210mg lofepramine.
> 4mg clonazepam (Klonopin).
> 1.5g L-Tryptophan - now ditched coz of excessive hypersomnia.


I would say that imipramine demonstrates a greater success rate than desipramine.

When combined with an MAOI, imipramine might have a greater potential to produce serotonin toxicity when compared to lofepramine. I think lofepramine is a prodrug that is converted to desipramine in the body. Desipramine is selective enough for NE that it be safer with an MAOI. I experience a degree of serotonin syndrome when I combine imipramine with Nardil.

How did you come to take 90mg of Marplan? Are you convinced that it helps you more than 60mg? I am in the process of titrating Marplan. However, I doubt that my doctor will go any higher than 60mg.

Thanks.


- Scott


The measure of achievement lies not in how high the mountain,
but in how hard the climb.

The measure of success lies only in how high one feels he must
climb to get there.

 

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