Posted by tensor on April 6, 2010, at 13:55:51
In reply to Re: Quick poll: Amitriptyline or Doxepin, posted by ed_uk2010 on April 6, 2010, at 13:48:29
> I wouldn't recommend doxepin for severe depression. It's mainly an antihistamine - a very strong one indeed! Very low doses are useful for chronic insomnia. It's also used to relieve itching eg. in urticaria or uncontrolled eczema. Doxepin is a very weak 5-HT/NE re-uptake inhibitor. It's not as well established for depression as other TCAs.
>
> Amitriptyline is certainly an effective antidepressant but it's very sedating. Why not consider a less sedating tricyclic such as imipramine? Also, clomipramine causes some sedation but not as much as amitriptyline.
>
>Thanks for your input. I have no experience from imipramine but I have used clomipramine, I just can't remember how effective it was. Clomipramine vs. amitriptyline, hmm.. not easy. :)
Btw, how come clomipramine does not have FDA approval for the treatment of depression?
/Mattias
poster:tensor
thread:942481
URL: http://www.dr-bob.org/babble/20100406/msgs/942484.html