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Re: Parnate: drowsy in morning, insomina at night? » George Romero

Posted by shalhevet on April 4, 2010, at 21:34:12

In reply to Re: Parnate: drowsy in morning, insomina at night? » shalhevet, posted by George Romero on April 4, 2010, at 17:32:27

I've been taking 80mg pretty consistently for awhile now (a few months at this dose), playing with 100mg sometimes. The insomnia/fatigue thing has been a constant from day 1, though. I recently mentioned it here:
http://www.dr-bob.org/babble/20100318/msgs/940842.html

(And I made a mistake in my post: I responded at 70mg and 90mg; 50mg and 80mg were what I backed off to when it pooped out. Not that it's super relevant, just mentioning it).

Right now I do 20-40-20, at 7:00, 10:00, and noon. The doses are split up mainly because of the hypotension issue. I don't find Parnate stimulating (plenty of sympathomimetic side-effects, though...), so the timing isn't huge as long as I get it all before 2:00ish. I also take Dexedrine and try to not take them too closely together, or I sometimes end up with urinary hesitancy.

I've been wondering if the intense fatigue I experience may be a REM rebound. I can't sleep at all at night without a sedative (and I wake up tired), and I'll sometimes have very deep 2-3 hour naps during the day and I'll be totally helpless to it, but it'll be my most resorative sleep. I've had 12+ hour crashes like that, too, no sleep aid or anything. I'd find it hard to believe that I have narcolepsy, so I'm thinking that perhaps a reason for the weird insomnia+fatigue combo is that Parnate wrecks sleep architecture somehow beyond simply making it difficult to fall asleep.


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