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Re: MAO inhibitors and heart disease: a new study.

Posted by SLS on March 17, 2010, at 11:37:52

In reply to Re: MAO inhibitors and heart disease: a new study. » kirbyw, posted by Netch on March 17, 2010, at 10:53:53

> Interesting, monoamine catabolites are toxic.
> Monoamine transporters seem to be there for a reason.

It is important for the neuron to sequester the monoamine neurotransmitters in the synaptic vesicle to protect them from cytosolic MAO. Here, the effective operation of the vesicular amine transporter (VAT) is critical.

Interesting article. As Linkadge indicates, it will prove informative to investigate whether or not other MAOIs produce a protective or therapeutic effect in heart failure.


- Scott

 

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