Posted by linkadge on March 15, 2010, at 11:03:10
I have been lately thinking that SSRI's might work better with less frequent dosing.
For instance, when I take an SSRI, I ususally feel a little bit worse initially. After the drug leaves the system, then I start to feel better than baseline.
Could it be that the improved mood actually occurs when the serotonin inhibition drops and there is the corresponding dopamine boost?
Similarly, people often report feeling better than usuall for a little while after withdrawl.
So, what about taking SSRI's less frequently? So that the transporter inhibition stops and the system has the opportunity to swing back the other way?
I seem to do better on escitalopram dosing every *other* day. But, if I go more than 2 or 3 days, then I start to feel worse.