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Re: Stimulants helping more over time?

Posted by West on March 14, 2010, at 10:35:53

In reply to Re: Stimulants helping more over time?, posted by alchemy on March 13, 2010, at 15:54:50

I would echo what linkage pointed out about depressive reactions and would personally not do well on any stimulant if not already stabilised on an antidepressant.

Immediate release ritalin and dex are not worth the hassle imo. Concerta is different. I don't notice it wearing off anymore. Dex-amp degrades mood whereas mph supports it. D-threo-mph, it's metabolite shows clinically relevant agonism of 5-Ht(1a) in guinea pigs, useful if taken with SSRis.

Add a 5ht(2c) antagonist and you're increasing NA/DA firing.

 

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