Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Moclobemide

Posted by SLS on March 11, 2010, at 17:51:08

In reply to Re: Moclobemide » SLS, posted by SLS on March 11, 2010, at 17:18:56

Concomitant use of modafinil and tranylcypromine
in a patient with narcolepsy: a case report
by
Clemons WE, Makela E, Young J.
Michael S. Aldrich Sleep Disorders Laboratory,
Department of Neurology, University of Michigan,
8D 8702 University Hospital,
Box 0117, 1500 East Medical Center Drive,
Ann Arbor, MI 48109-0117, USA
Sleep Med. 2004 Sep;5(5):509-11

ABSTRACT

This is a case report of a patient with narcolepsy treated simultaneously with modafinil and tranylcypromine. The concurrent use of these two medications is normally contraindicated based on theoretical concerns. To our knowledge this is the first report of the combined use of these two medications in a patient for any reason. This combination of medications was particularly effective in the treatment of the patient's narcoleptic symptoms and was well tolerated, with no evidence of the potential cardiovascular side effects. Due to modafinil's lack of sympathomimetic activity and unique pharmacological profile, it may be well tolerated with monoamine oxidase inhibitor's (MAOI's) in humans with respect to hemodynamic parameters and concerns of hypertensive crisis. Further investigation would help clarify cardiovascular safety issues in using this combined therapy. We believe that with proper informed consent from the patient and careful monitoring, a combination of an MAOI and modafinil may be a viable treatment alternative in refractory cases of narcolepsy.

---------------------------------------

I wish I knew exactly what the theoretical basis is for contraindicating the combination of modafinil (Alertec) and MAOI. It isn't immediately obvious to me.


- Scott

 

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:SLS thread:939114
URL: http://www.dr-bob.org/babble/20100305/msgs/939199.html