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Re: SSRI vs SNRI - Efficacy Comparison Article (lo » SLS

Posted by conundrum on March 6, 2010, at 8:44:54

In reply to Re: SSRI vs SNRI - Efficacy Comparison Article (lo » desolationrower, posted by SLS on March 6, 2010, at 1:29:14

The interesting thing is that atomoxetine can cause slow onset depression. REboxetine wasn't even approved in the US because it wasn't regarded as effective, but desipramine is an effective AD and they are all NRIs. Its weird there is such a huge difference in efficacy for depression among selective NRIs but not among SSRIs.

Its also interesting that in that meta study of the 12 most effective ADs the top 4:Mirtazapine,Venlfaxine,Lexapro, and Sertraline, have linear pharmokinetics. Other drugs that have weird metabolisms like fluoxetine and buproprion are further down the list. Maybe the more effective drugs are more effective because responses at the normal doses are similar among slow metabolizers and fast metabolizers.

 

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