Posted by X-ray on March 4, 2010, at 7:19:56
In reply to Re: Heroic combos - FDA approved... » highhatsize, posted by TriedEveryDrug on March 2, 2010, at 17:57:12
Stephen M. Stahl:
Heroic combo 3: High-dose venlafaxine plus NRI
The NRI could be either selective reboxetine or a nonselective TCA such as desipramine, maprotilene, nortriptyline, or protriptyline.
Heroic combo 7: Mirtazapine plus NRI
Reboxetine is better tolerated with mirtazapine than TCAs for this purpose.
Heroic combo 10: SSRI plus NRI
The preferred NRI is selective reboxetine, as there are no interactions.
Nonselective TCAs that are preferential NRIs such as desipramine, maprotilene, nortriptyline, or protriptyline can be combined
if plasma drug levels of the TCA are monitored, especially if fluoxetine or paroxetine is the SSRI chosen.
P.S. I'm on Heroic combo 8: Mirtazapine plus NDRI (bupropion).