Posted by softheprairie on January 13, 2010, at 5:15:30
In reply to Least sedating TCA, posted by Laney on January 10, 2010, at 13:36:33
Yeah, I was going to suggest desipramine also.
It's significantly lower incidences of sedation or weight gain were much of the cause of me asking to try it, and it has been a winner for me!
I do have cardiac side effects, though. EKG showed just plain high heartrate (tachycardia), not abnormal rhythm other than fast, which is controlled with a beta blocker that has been added (nebivolol/Bystolic). My recent EKG was normal, I was told.I will say, I am still on it, but unfortunately, there was a new FDA warning that came out about it Dec. 2, 2009 (not bad that the warning was issued, but that it seems to be warranted/true). There is risk of sudden death on it, particularly if one has a family history of sudden death due to heart attack, which is exactly my case. In consultation with my pdoc, I tried to decrease my does of desipramine, from 300 mg/day. I went to 250, on my way to try 200, but I never got to the 200. My mood was worse at the 250. I gave it 13 days, and then didn't want to keep the worse mood, and went back to the 300. Maybe you can do well with it at a lower dose, which is safer.
poster:softheprairie
thread:933151
URL: http://www.dr-bob.org/babble/20100113/msgs/933463.html