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Re: Lar ? Toxicology question?(if time + interest )

Posted by Elroy on January 12, 2010, at 0:57:58

In reply to Lar ? Toxicology question?(if time + interest ), posted by tea on January 10, 2010, at 17:16:22

> http://www.jimmunol.org/cgi/content/full/173/1/42
>
> in support of my comment of non TOTAL blockage of receptors
************************************************


You are comparing APPLES and ORANGES.

Naltrexone (full strength) operates in a fully different manner than LDN. The "inventor" of Naltrexone, in doing some further studying of the Immune System and Endorphin production realized that LDN does approximately the OPPOSITE of full strength LDN.

Also this study:

"Opioid Antagonist Naltrexone Disrupts Feedback Interaction between µ and {delta} Opioid Receptors in Splenocytes to Prevent Alcohol Inhibition of NK Cell Function" is a study in using the full strength levels of Naltrexone as a potential aid in alcohol addiction / withrawal recovery. Most tests have shown it to be only 25 - 50% effective in that regard.

That is because alcohol is NOT an opiate and Naltrexone is specifically chemically designed to shut down Endorphin production produced by the taking of opiates (heroin, morphine, opium, etc.).

You take full-strength Naltrexone around the clock to prevent from getting high when taking opiates. That is why it generally only works well in a controlled environment (like a sanitorium) as patients will intentionally miss doses in order to get high again with opiates.
Full strength Naltrexone - once again - stops your body from getting special higher level Endorphins created and secreted by the taking of Opiates - not necessarily ALL of your body's "general, basic, day-to-day Endorphins").

LDN on the other hand - at the right dosage levels - does stop all normal Endorphin products (as well as highly dilute Endorphins produced by opiates such as morphine pain killers - which is why they caution, for example, cancer patients on morphine for pain to NOT take LDN until a non opiate pain killer med can be established (if possible).

I - for example - take Darvon for my Cushing's recovery joint and muscle pains and aches and the LDN doesn't dilute its effects at all... because Darvon is NOT an opiate and does not work by creating special higher intensity endorphins as pain killers.

So there is no "support of [your] comment of non TOTAL blockage of receptors"... as, like I said, you are comparing apples and oranges.

Reading up a LOT of material on a subject (and it appears that you are mixing regular Naltrexone right in with Low Dose Naltrexone in your research - in and of itself doesn't mean that you necessarily understand the specific details, processes, and functions about which you are reading.

Hint: In researching on LDN, if you come to any article or study or clinical trial that is discussing Naltrexone versus LDN, completely skip it... or you will simply ended up even more confused.

Also, I boosted my LDN levels from 1.5 mg to 3.0 mg Sunday (i think it was) and by today have noted a very strong difference... still not what I fully expect but my doc wants me to stay at this level for two weeks before moving to 4.5 mg --- but it is my belief that it will be at 4.5 mg where I begin to notice the full effects of LDN.

Also... I have had ZERO side effects from LDN.

No headaches (in fact it cleared up a steady headache that i would get every morning since the flank pain started with the - suspected - kidney area inflammation).

No "weird dreams".

Vivid dreams... Yes. But I have had vivid dreams ever since I started taking Melatonin (1mg) regularly) and the current ones are no more vivid than the ones that I had prior to LDN).

The only side effect that i notice is that if I take the LDN at 10 PM and end up staying up until 1 AM (like on the computer, I'll feel somewhat "crappy" -- which is at it should be as the LDN is shutting down my Endorphin production... I should wait and take it JUST BEFORE the time I actually go to bed.


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poster:Elroy thread:919880
URL: http://www.dr-bob.org/babble/20100103/msgs/933326.html