Posted by tea on December 28, 2009, at 3:22:58
In reply to LDN Low Dose Naltrexone Questions, posted by Bob on October 5, 2009, at 22:45:53
> I might be behind the curve here, but I recently came across some literature espousing Low Dose Naltrexone for, among other things, fibromyalgia symptoms. The prevailing recommendations suggest taking it some time between 10pm and 2am before going to bed. The theory is that it inhibits endogenous opiate receptors during the time of peak activity during sleep (I guess) thus raising the available levels of endorphins available. The usual doses for things like addiction problems is 50mg, but the LDN regimen calls for building up the dose by 1.5mg increments to a total of only 4.5mg.
> Anyway, I'm wondering if anyone here has any experience with LDN. I got the prescription for 1.5mg 3 times per day and took the first pill two nights ago. The next day I woke up refreshed and felt unusually calm and relaxed, yet energetic and focused. All my fibro type aches, pains and muscle problems seemed to evaporate and I was well enough to be able to clean and arrange a significant portion of the house. It was a day like I hadn't had in a long time.
I think the idea with ldn is to take only once a day (ie intermittently so your recptors are not continually dosed - ie they just have the 'hita' lasts no longer than 4 hrs (My understanding) and the response to the blockade of the recptors is what is supposed to help. So 3 times a day would build up and stop working.
Some poeple whose metabolism is a little slow(like hypothryoid) semt o function better ecven taking once every 2 or 3 days.. to allow sufficinet time for recptors not to be blocked. I haven't worked it out as yet myself!