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augmenting buspirone with melatonin

Posted by iforgotmypassword on December 18, 2009, at 15:19:28

does anyone have much understanding of how melatonin potentiates 5-ht1a receptor responses? (if i am even under the right initial impression that this is the case.) what kind of doses may be helpful to augment buspirone if it can do this? is it via the melatonin 1 or 2 receptors, or via some other mechanism?

the concept is interesting me for a few reasons:

all my life i have slept with a bright light on. i cannot sleep in the dark.

i have been reading about correlations between pineal "calcifications" (i have a lesion, presumed to be a cyst), presumed dysfunction in melatonin synthesis, and tardive dyskinesia. i wonder if may apply to tardive syndromes in general.

certainly my accidental buspirone megadosing experience let me feel the most natural, aware, unafraid and sober i have ever in a very long time. maybe i need such high doses as the 5-ht1a receptors lack a piece of the puzzle in allowing them to function normally?


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poster:iforgotmypassword thread:929841
URL: http://www.dr-bob.org/babble/20091217/msgs/929841.html