Posted by SLS on December 16, 2009, at 6:27:27
In reply to Re: Extended Release Seroquel Approved For Depression » SLS, posted by Ron Hill on December 16, 2009, at 0:14:55
> > One must consider that Seroquel has a major metabolite that is a norepinephrine reuptake inhibitor; ...
> Due to the NRI metabolite, does this mean that Seroquel should not be combined with an MAOI, like Nardil or Parnate, due to the risk of a hypertensive crisis?
> -- Ron
> PS If you can't reply right now due to your pain of Parnate withdrawal, I understand.
I don't know. One might speculate that if the NRI desipramine is compatable with MAOIs, so might be Seroquel. I am having a hard time remembering anyone that has tried it. If one were to attempt to add Seroquel to an ongoing treatment with a MAOI, it would be prudent to titrate the dosage of the Seroquel carefully.